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 These Hormones Are Making 3,000+ Wonderful Cells TOXIC

 

By Kevin DiDonato MS, CES--Level 1 Certified Precision Nutrition and Certified Personal Trainer


There are many people who are trying to lose weight.

However, losing weight today is a much different process that it has been previously.

Factors such as diet and physical activity levels are a lot different today than in previous years.

This could account for some of the changes that have led to the development of “sick” fat cells, commonly referred to as "toxic fat cells."

Today, research shows that fat cells should be considered an endocrine organ similar to your thyroid and pancreas, due to their ability to secrete hormones that could affect metabolism.

Fat cells release many hormones which help regulate energy levels in your fat cells and boost metabolism and fat burning.

However, research also shows that fat cells release pro-inflammatory molecules, which can increase inflammation in your fat cells.

This can lead to resistance of your cells to the powerful hormones that are responsible for boosting fat metabolism.

The following is a list of the top three Adipokines That You Need To Worry About

SAA

SAA is another name for serum amyloid A which is an acute phase protein.

Research shows that high levels of SAA can be associated with increased inflammation and could also play a role in the development of atherosclerosis.

Doctors use SAA levels to determine the extent of cardiovascular diseases, or to determine if there was a cardiovascular event.

SAA is an important molecule that also has been associated with insulin resistance, obesity, and Type II Diabetes.

It can be secreted by fat tissue (adipocytes) and, in cases of diabetes and obesity, there is an increase in the production and the secretion of SAA.

The problem with high levels of SAA, according to research, is that increased levels of SAA alter the way the body processes lipoproteins (cholesterol).

In fact, it has been shown that SAA promotes the ingestion of HDL cholesterol (your good cholesterol) by macrophages, which reduces the cardio-protective benefits of HDL cholesterol.

Increased levels of SAA could potentially lead to systemic inflammation, heart disease, and toxic fat cells.

IL-6

IL-6 is the abbreviated term for interleukin-6, which is a pro-inflammatory cytokine release by many different cells in your body and your fat cells.

When inflammation is not present, however, roughly 15 to 30 percent of IL-6 released comes from adipose tissue.

There are two different types of fat in your body: adipose and visceral.

IL-6 is released by both fat tissues, however, visceral fat releases roughly three times the amount of IL-6 compared to white adipose tissue.

IL-6 affects many different cells in your body and, according to some research, is the main driving force behind the release of C-reactive proteins from your liver.

There has also been a positive relationship between IL-6 levels (release from adipose tissue) and circulating C-reactive protein levels.

IL-6 cytokines released from visceral adipose tissue could result in increased health risks.

It has been shown that increased IL-6 from intra-abdominal fat (visceral) could impair liver metabolism.

This could lead to an increased release of triglycerides from the liver, which is termed visceral-related triglyceridemia.

Higher triglycerides can lead to heart disease and other chronic diseases.

IL-6 also could increase insulin resistance, which makes it harder for your body to process sugar from your blood, liver, and muscles.

This has the potential to increase inflammation and decrease the release of beneficial hormones such as Adiponectin and Leptin from your fat cells.

Visfatin

Visfatin is a new molecule that has been discovered that could also lead to increased levels of inflammation.

Made and secreted by visceral adipose tissue, research shows, visfatin is a result of adipocyte (fat cells)

differentiation.

Adipocyte differentiation is a process where unspecialized cells take on the specialized features of adipose cells, in order to synthesize and store dietary fat.

Research suggests that visfatin could be an inflammatory mediator, and is responsible for the increased activation of pro-inflammatory mediators such as TNF-alpha, MP-9, and IL-8.

Free Your Toxic Fat Cells

Toxic fat cells could help prevent weight loss and increase the secretion of pro-inflammatory cytokines, which can increase inflammation levels in your fat cells and in your body.

Diet and exercise have been shown to increase weight and fat loss, potentially returning your fat cells back to healthy cells.

However, when your fat cells are toxic, either resistance to powerful fat burning hormones or the secretion of these hormones may be decreased.

By making your fat cells healthy again, you could increase fat loss and boost your metabolism in the process.

 

References:

Antuna-Puente, B.  Fevee,m B.  Fellahim, S.  Bastard, JP.  Adipokines: The missing link between insulin resistance and obesity.  Diabetes $ Metabolism.  2008. Vol. 34:pp.2-11.